Anti-MRM1抗體,線(xiàn)粒體rRNA甲基轉(zhuǎn)移酶1抗體產(chǎn)品介紹：MRM1 is a 353 amino acid protein that localizes to the mitochondrion and belongs to the RNA methyltransferase trmH family. Expressed as two alternatively spliced isoforms, MRM1 specifically methylates the ribose of guanosine G-2270 in the peptidyl transferase center of the mitochondrial large ribosomal RNA (21S). The gene encoding MRM1 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

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保存條件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
連續(xù)使用時(shí)4°C存儲(chǔ)，保質(zhì)期六個(gè)月，*存儲(chǔ)時(shí)建議分裝為10ul以上小包裝-20°C存儲(chǔ)，并避免反復(fù)凍融，保質(zhì)期一年。

產(chǎn)品名稱(chēng) Anti-MRM1抗體,線(xiàn)粒體rRNA甲基轉(zhuǎn)移酶1抗體

產(chǎn)品編號(hào) BYK-17763R

英文名稱(chēng) MRM1
中文名稱(chēng) 線(xiàn)粒體rRNA甲基轉(zhuǎn)移酶1抗體
別    名 A530065E19Rik; ENSMUSG00000054212; FLJ22578; Mitochondrial large ribosomal RNA ribose methylase; Mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae); MRM1; MRM1_HUMAN; OTTMUSP00000008034; RGD1566232; RP23-293L24.6; rRNA methyltransferase 1, mitochondrial.
研究領(lǐng)域 細(xì)胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  線(xiàn)粒體  表觀遺傳學(xué)       

抗體來(lái)源 Rabbit or Mouse
克隆類(lèi)型 Polyclonal or Monoclonal
交叉反應(yīng)、產(chǎn)品應(yīng)用 （具體交叉反應(yīng)與產(chǎn)品應(yīng)用請(qǐng)）
分 子 量 19kDa

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